alexisWhat does Alexis mean? A lexis as a boys' name (also used more widely as girls' name Alexis) is pronounced a-LEX-iss. It is of Greek orin, and the meaning of Alexis is defender. OftenLauren Alexis (@laurenalexis_x) on | 65.7M Likes. 2.9M Followers. I hope u have a good day 🥺.Watch Lauren Alexis's popular videos: It WAS raining, I neeeeeeed to know. Join